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Researchers have also noted reductions in TGF-?-driven fibrosis, pointing to possible relevance in models of cardiac scarring, pulmonary fibrosis, and chronic inflammatory injury

However, these clinical trials were conducted in Croatia and published in the early 2000s

Dopamine, which acts as a neurotransmitter in the CNS is well known to not cross the BBB [68] due to lack of specific transporter and active metabolism in brain endothelial cells